2-Chloro-5-methoxyaniline, CAS No. 2401-24-3

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

2401-24-3

Catalog No. EBD45421

CAS 2401-24-3

Name 2-Chloro-5-methoxyaniline

Get Quote

Basic Information

Synonyms: 2-Chloro-5-methoxyaniline 6-chloro-meta-anisidine 3-Amino-4-chloroanisole 2-chloro-m-anisidine 3-amino-4-chloroanisolehydrochloride 6-chloro-meta-anisidinehydrochloride 2-chloro-5-methoxyanilinehcl 6-chloro-m-anisidine(nh2=1),hcl

Molecular Formula: C7H8ClNO

Molecular Weight: 157.6

MDL Number: MFCD00047830

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

2-Chloro-5-methoxyaniline is an organic compound featuring an aniline core substituted with a chlorine atom at the 2-position and a methoxy group at the 5-position. It is a solid at room temperature and serves as a versatile aromatic amine building block in synthetic chemistry. This compound is primarily utilized as a key pharmaceutical intermediate. It is a crucial precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those belonging to the benzimidazole class. A prominent application is its use in the industrial-scale production of Omeprazole, a widely prescribed proton pump inhibitor for treating acid-related gastrointestinal disorders. The synthesis pathway typically involves the cyclization of this aniline derivative with other reagents to construct the benzimidazole core structure of the drug. Handling requires standard precautions for aromatic amines, including the use of personal protective equipment to avoid inhalation, ingestion, or skin contact.

Physical Properties

Melting Point: 23-27 °C

Boiling Point: 135-137°C 12mm

Flash Point: >110 °C

Density: 1.261 g/mL at 25 °C

Refractivity: n20/D 1.588

Analytical Data

Appearance: green gray powder.