Articaine hydrochloride, CAS No. 23964-57-0

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23964-57-0

Catalog No. EBD51009

CAS 23964-57-0

Name Articaine hydrochloride

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Basic Information

Synonyms: Articaine HCl Methyl4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylatehydrochloride Articainehydrochloride Aarticainehydrochloride Articainehydrochloride[USAN] 2-Thiophenecarboxylicacid,4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-,methylester,monohydrochloride 4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylicacidmethylesterHCl ArticaineHCl Carticainehydrochloride HOE045 HOE40045 Methyl4-methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylate,monohydrochloride Septocaine UNII-QS9014Q792 Ultracain Ultracaine 2-Thiophenecarboxylicacid,4-methyl-3-(2-(propylamino)propionamido)-,methylester,monohydrochloride Methyl4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-2-thenoatemonohydrochloride methyl4-methyl-3-[(N-propylalanyl)amino]thiophene-2-carboxylatehydrochloride(1:1) 4-Methyl-3-(2-(propylamino)pr

Molecular Formula: C13H21ClN2O3S

Molecular Weight: 320.84

MDL Number: MFCD00190157

Categories: Medicinal Chemistry > APIs and Their Salts > Anesthetics and Analgesics Medicinal Chemistry > Drug Impurities and Reference Standards > Impurity Standards

Product Description:

Articaine hydrochloride is a local anesthetic of the amide type, chemically known as 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride. It is a white to off-white crystalline powder that is freely soluble in water and ethanol. Its molecular structure features a thiophene ring, which distinguishes it from other common amide-type anesthetics like lidocaine. Its primary and most significant application is in dentistry as a local anesthetic for procedures such as routine restorations, extractions, and periodontal surgery. Articaine is often formulated with epinephrine (adrenaline) as a vasoconstrictor to prolong its duration of action and reduce systemic absorption. It is valued for its rapid onset, profound anesthetic effect, and good diffusion through soft and hard tissues, making it particularly effective for mandibular block and infiltration anesthesia. Beyond its use as an active pharmaceutical ingredient (API) in final drug formulations, articaine hydrochloride is also crucial in pharmaceutical quality control. It serves as a reference standard or impurity standard in analytical methods (e.g., HPLC) to ensure the identity, potency, and purity of articaine-based pharmaceutical products, detecting and quantifying related substances or degradation products.

Physical Properties

Color: white to beige

Boiling Point: 440.6 °C at 760 mmHg

Flash Point: 220.3 °C

Storage: 2-8°C

Analytical Data

Appearance: white powder