2,4-Dihydroxypyrimidine-5-carboxylic acid, CAS No. 23945-44-0

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23945-44-0

Catalog No. EBD20912

CAS 23945-44-0

Name 2,4-Dihydroxypyrimidine-5-carboxylic acid

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Basic Information

Synonyms: Uracil5-carboxylicacidHydrate Uracil-5-carboxylicacidHydrate 2,4-Dihydroxypyrimidine-5-carboxylicacidhydrate 2,4-dihydroxypyrimidine-5-carboxylicacid isooroticacid uracil-5-carboxylicacid

Molecular Formula: C5H4N2O4

Molecular Weight: 156.1

MDL Number: MFCD00006023

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

Uracil-5-carboxylic acid is a heterocyclic organic compound featuring a uracil core substituted with a carboxylic acid group at the 5-position. It serves as a crucial synthetic intermediate in medicinal chemistry and biochemistry. Its primary application is in the synthesis of nucleoside analogs and modified nucleic acid bases. As a versatile building block, the carboxylic acid group allows for further derivatization, enabling the creation of novel compounds with potential biological activity. It is particularly relevant in the development of antiviral and anticancer agents, where modifications to the nucleobase structure are explored to enhance efficacy or alter pharmacokinetic properties. While not a direct component of natural nucleic acids, uracil-5-carboxylic acid is a fundamental scaffold for constructing more complex molecules used in life science research and drug discovery programs targeting nucleotide metabolism pathways.

Physical Properties

Melting Point: 283 °C (dec.)(lit.)

Boiling Point: 564.9 °C at 760 mmHg

Flash Point: 295.4 °C

Density: 1.642 g/cm3

Analytical Data

Appearance: white to slightly yellow crystalline powder