Ambroxol hydrochloride, CAS No. 23828-92-4

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23828-92-4

Catalog No. EBD28403

CAS 23828-92-4

Name Ambroxol hydrochloride

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Basic Information

Synonyms: trans-4-[[(2-Amino-3,5-dibromo-phenyl)methyl]amino]-cyclohexanolhydrochloride Ambroxolhydrochloride MUCOSOLVAN TRANS-4-((2-AMINO-3,5-DIBROMOBENZYL)AMINO)CYCLOHEXANOL,HCL TRANS-4-[[(2-AMINO-3,5-DIBROMOPHENYL)METHYL]AMINO]CYCLOHEXANOLMONOHYDROCHLORIDE 2-AMINO-3,5-DIBROMO-N-[TRANS-4-HYDROXYCYCLOHEXYL]BENZYLAMINEHYDROCHLORIDE AMBROXOLHCL AMBROXOLHYDROCHLORIDE(EP2001/CP2000) AMBROXOLHYDROCLORIDE 4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanolhydrochloride(1:1) N-(2-amino-3,5-dibromobenzyl)-4-hydroxycyclohexanaminium trans-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanolhydrochloride trans-4-[[(2-ami

Molecular Formula: C13H19Br2ClN2O

Molecular Weight: 414.56

MDL Number: MFCD00078932

Categories: Medicinal Chemistry > APIs and Their Salts > Respiratory Drugs Medicinal Chemistry > Pharmaceutical Excipients > Other Pharmaceutical Excipients

Product Description:

Ambroxol hydrochloride is a widely used active pharmaceutical ingredient (API) belonging to the class of mucolytic agents. It is a metabolite of bromhexine and acts as a secretolytic and secretomotoric agent. Chemically, it is a derivative of vasicine, featuring a trans-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol structure. Its primary and most significant application is in the treatment of respiratory diseases associated with viscid or excessive mucus. It works by stimulating the synthesis and release of surfactant from type II pneumocytes and by depolymerizing mucopolysaccharide fibers directly, thereby reducing sputum viscosity and facilitating expectoration. It is formulated in various dosage forms such as tablets, syrups, oral solutions, and inhalants. Beyond its role as an API, ambroxol hydrochloride is also investigated for its potential neuroprotective and anti-inflammatory properties. In some specific formulations, it may function as an excipient to enhance the solubility or delivery of other drugs. It is generally well-tolerated, with common side effects including gastrointestinal discomfort.

Physical Properties

Melting Point: 233-234.5°C

Boiling Point: 468.6 °C at 760 mmHg

Flash Point: 237.2 °C

Density: 1.612 g/cm3

Storage: 2-8°C

Analytical Data

Appearance: white crystalline powder