(R)-(-)-1,2,3,4-Tetrahydro-1-naphthylamine, CAS No. 23357-46-2

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23357-46-2

Catalog No. EBD5259

CAS 23357-46-2

Name (R)-(-)-1,2,3,4-Tetrahydro-1-naphthylamine

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Basic Information

Synonyms: (1R)-1,2,3,4-Tetrahydro-1-naphthalenamine (1R)-1,2,3,4-Tetrahydronaphthalen-1-amin (1R)-1,2,3,4-Tetrahydronaphthalen-1-amine 1-naphthalenamine,1,2,3,4-tetrahydro-,(1R)- (R)-1-Amino-1,2,3,4-tetrahydronaphthalene (R)-1,2,3,4-Tetrahydro-1-naphthylamine (S)-(+)-2-Pyrrolidinemethanol S-2-Hydroxymethyl-pyrrolidine (R)-(-)-1,2,3,4-Tetrahydro-1-naphthylamine

Molecular Formula: C10H13N

Molecular Weight: 147.22

MDL Number: MFCD00671629

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(R)-(-)-1,2,3,4-Tetrahydro-1-naphthylamine is a chiral amine compound featuring a tetralin (1,2,3,4-tetrahydronaphthalene) backbone. It is a versatile chiral building block, with the (R)-enantiomer being of particular synthetic interest. Its primary application is as a key chiral intermediate in the pharmaceutical industry. It is notably used in the synthesis of various active pharmaceutical ingredients (APIs), including certain calcium channel blockers and other cardiovascular drugs. The chiral tetralin amine scaffold is a privileged structure in medicinal chemistry, often serving as a core component to impart specific biological activity and stereoselectivity. Due to its well-defined chiral center and amine functionality, it is also widely employed in asymmetric synthesis as a chiral auxiliary or ligand precursor in academic and industrial research settings. It serves as a fundamental starting material for constructing more complex, biologically active molecules.

Physical Properties

Boiling Point: 118-120 °C/10 mbar

Flash Point: 112 °C

Density: 1.002 g/mL at 25 °C

Refractivity: n20/D 1.565

Safety Information

Packing Level: III

Hazard Category: 8

Transport Codes: 2735PSN1