L-Glutamic acid, 1,5-dimethyl ester, hydrochloride (1:1), CAS No. 23150-65-4

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23150-65-4

Catalog No. EBD1914785

CAS 23150-65-4

Name L-Glutamic acid, 1,5-dimethyl ester, hydrochloride (1:1)

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Basic Information

Synonyms: L-glutamicaciddimethylesterhydrochloride H-Glu(OMe)-OMe.HCl H-Glu(OMe)-OMe*HCl DimethylL-glutamatehydrochloride~H-Glu(OMe)-OMe.HCl H-Glu(OMe)-OMe稨Cl dimethylL-glutamate (2S)-1,5-dimethoxy-1,5-dioxopentan-2-aminiumchloride H-Glu(OMe)-OMe·HCl (S)-Dimethyl2-aminopentanedioatehydrochloride (S)-Dimethyl2-aminopentanedioatehydrochloride；H-Glu(OMe)-OMe*HCl

Molecular Formula: C7H14ClNO4

Molecular Weight: 211.64

MDL Number: MFCD00038879

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

L-Glutamic acid dimethyl ester hydrochloride is a protected derivative of the natural amino acid L-glutamic acid. It is a white to off-white crystalline powder with the molecular formula C7H14ClNO4. The compound features the L-configuration and exists as a hydrochloride salt, with the carboxylic acid side chain protected as a methyl ester. This compound serves as a crucial chiral building block in pharmaceutical synthesis. Its primary application is as a key intermediate in the production of various bioactive molecules and active pharmaceutical ingredients (APIs). It is particularly valuable for introducing the L-glutamic acid moiety into peptide chains or other complex structures while offering orthogonal protection strategies for the carboxylic acid groups, facilitating selective chemical transformations. As a protected amino acid derivative, it is widely used in solid-phase peptide synthesis (SPPS) and solution-phase peptide chemistry. It finds utility in the research and development of neuroactive peptides, metabolic regulators, and other therapeutic agents where the glutamyl residue is pharmacologically important. The dimethyl ester protection enhances its solubility in organic solvents, making it suitable for a range of coupling reactions.

Physical Properties

Melting Point: 89-90°C

Boiling Point: 224.3 °C at 760 mmHg

Flash Point: 76.7 °C

Density: 1.129 g/cm3

Refractivity: 26 ° (C=5, H2O)

Storage: 2-8°C