1-(9,10-Dihydro-6H-6,10-methanoazepino[4,5-g]quinoxalin-8(7H)-yl)-2,2,2-trifluoroethanone, CAS No. 230615-70-0

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230615-70-0

Catalog No. EBD21936

CAS 230615-70-0

Name 1-(9,10-Dihydro-6H-6,10-methanoazepino[4,5-g]quinoxalin-8(7H)-yl)-2,2,2-trifluoroethanone

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Basic Information

Synonyms: 1-(9,10-Dihydro-6H-6,10-methanoazepino[4,5-g]quinoxalin-8(7H)-yl)-2,2,2-trifluoroethanone 2,2,2-trifluoro-1-(6,7,9,10-tetrahydro-6,10-methano-8H-pyrazino[2,3-h][3]benzazepin-8-yl)ethanone 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine,7,8,9,10-tetrahydro-8-(trifluoroacetyl)- 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine,7,8,9,10-tetrahydro-8-(trifluoroacetyl)-(9CI) 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine 8-(trifluoroacetyl)-7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline

Molecular Formula: C15H12F3N3O

Molecular Weight: 307.27

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is a complex heterocyclic compound featuring a fused pyrazino[2,3-h][3]benzazepine core structure. This molecule is characterized by a bridged methano group and a trifluoroacetyl substituent, which are key structural motifs influencing its physicochemical properties and biological activity. This compound is primarily known as a key intermediate in the synthesis of potent and selective dopamine D4 receptor antagonists. Research and patent literature indicate its critical role in the development pathway of novel antipsychotic agents targeting schizophrenia and other central nervous system disorders. The trifluoroacetyl group is a common pharmacophore in medicinal chemistry, often used to modulate metabolic stability and receptor binding affinity. As a specialized synthetic building block, its application is highly focused within pharmaceutical research and development. It is not a commodity chemical and is typically used in advanced stages of drug candidate synthesis. Handling requires standard laboratory precautions for organic compounds, with attention to its specific stability and solubility profile.

Physical Properties

Melting Point: 164-166 °C

Boiling Point: 491.9 °C at 760 mmHg

Flash Point: 251.3 °C

Density: 1.449 g/cm3