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    22532-62-3

    Catalog No. EBD489770

    CAS 22532-62-3

    Name 4-bromo-2-hydroxybenzaldehyde

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    Basic Information

    Synonyms: 4-Bromo-2-hydroxybenzaldehyde Benzaldehyde,4-bromo-2-hydroxy- 4-Bromosalicylaldehyde 4-Bromo-2-hydroxy-benzaldehyde

    Molecular Formula: C7H5BrO2

    Molecular Weight: 201.02

    MDL Number: MFCD06252606

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers

    Product Description:
    4-Bromo-2-hydroxybenzaldehyde is a bifunctional aromatic building block featuring a bromine atom, a hydroxyl group, and an aldehyde group on a benzene ring. Its molecular formula is C7H5BrO2, with a molecular weight of 201.02 g/mol. The compound exists as a solid at room temperature and is commonly used in organic synthesis. This compound serves as a versatile intermediate in the preparation of pharmaceuticals, agrochemicals, and fine chemicals. The aldehyde group allows for condensation reactions (e.g., Schiff base formation), while the bromine atom enables cross-coupling reactions such as Suzuki or Heck couplings. The hydroxyl group can be further functionalized via etherification or esterification. In medicinal chemistry, it is frequently employed as a key fragment for constructing heterocyclic compounds, including benzoxazoles and salicylaldehyde derivatives, which are relevant to drug discovery efforts targeting neurological and inflammatory diseases. Due to its reactive sites, 4-bromo-2-hydroxybenzaldehyde is also utilized in the synthesis of ligands for metal complexes and as a precursor for fluorescent probes. It should be stored under inert atmosphere and protected from light to prevent degradation.
    Physical Properties

    Melting Point: 50-54 °C

    Boiling Point: 256.23 °C at 760 mmHg

    Flash Point: >110 °C

    Density: 1.737 g/cm3

    Safety Information

    Packing Level: III

    Hazard Category: 9

    Transport Codes: 3077

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