1-Bromo-3-(trifluoromethoxy)benzene, CAS No. 2252-44-0

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2252-44-0

Catalog No. EBD871307

CAS 2252-44-0

Name 1-Bromo-3-(trifluoromethoxy)benzene

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Basic Information

Synonyms: 1-Bromo-3-(trifluoromethoxy)benzene Anisole,m-bromo-alphaalphaalpha-trifluoro- BUTTPARK91\57-27 M-BROMO(TRIFLUOROMETHOXY)BENZENE 3-(TRIFLUOROMETHOXY)BROMOBENZENE 3-BROMO-ALPHA,ALPHA,ALPHA-TRIFLUOROANISOLE 3-BROMO(TRIFLUOROMETHOXY)BENZENE 3-Bromo-1-(trifluoromethoxy)benzene m-Bromotrifluoromethoxybenzene 1-bromo-3-[(trifluoromethyl)sulfanyl]benzene buttpark9157-27 3-Bromotrifluoromethoxybenzene

Molecular Formula: C7H4BrF3O

Molecular Weight: 241.01

MDL Number: MFCD00040943

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Materials Chemistry > Optoelectronic and Organic Semiconductor Materials > OLED and Organic Optoelectronic Precursors

Product Description:

1-Bromo-3-(trifluoromethoxy)benzene is an aromatic compound featuring both a bromine atom and a trifluoromethoxy group (-OCF₃) attached to a benzene ring. It is a colorless to pale yellow liquid with a molecular formula of C₇H₄BrF₃O and a molecular weight of 241.01 g/mol. This compound serves as a versatile and valuable building block in organic synthesis, particularly in cross-coupling reactions such as Suzuki, Stille, and Buchwald-Hartwig couplings. The bromine atom acts as an excellent leaving group, enabling the introduction of the 3-(trifluoromethoxy)phenyl moiety into more complex molecular architectures. Its primary application is in the research and development of advanced materials, especially as a key precursor for synthesizing organic light-emitting diode (OLED) materials, liquid crystals, and pharmaceuticals where the trifluoromethoxy group is desired for its unique electronic and lipophilic properties. The trifluoromethoxy group is a privileged structural motif known to enhance metabolic stability, membrane permeability, and binding affinity in bioactive molecules. Consequently, this bromobenzene derivative is widely used in medicinal chemistry for constructing drug candidates and in material science for creating functional organic semiconductors. It should be handled with care as an irritant and stored under inert conditions.

Physical Properties

Boiling Point: 156-158 °C

Flash Point: 63 °C

Density: 1.62 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.462(lit.)