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    223673-34-5

    Catalog No. EBD2321878

    CAS 223673-34-5

    Name (alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol

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    Basic Information

    Synonyms: (alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol (R)-2-(4-Nitrophenethylamino)-1-Phenylethanol

    Molecular Formula: C16H18N2O3

    Molecular Weight: 286.33

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates

    Product Description:
    (alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol is a chiral amino alcohol derivative. Its structure features a benzhydrol core substituted with a (4-nitrophenyl)ethylamino group, and the alpha carbon is in the R configuration, making it a valuable chiral building block. This compound is primarily utilized as a key chiral intermediate in pharmaceutical synthesis. Its specific application is in the synthesis of Solifenacin succinate, a muscarinic receptor antagonist used for the treatment of overactive bladder (OAB). The chiral center introduced by this intermediate is crucial for the biological activity of the final drug molecule. As a specialized pharmaceutical intermediate, it is not a common, general-purpose synthetic reagent. Its production and use are closely tied to the specific synthetic route for Solifenacin, highlighting its role in enabling the efficient and stereoselective construction of complex active pharmaceutical ingredients (APIs).
    Physical Properties
    mg g kg ml l t