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    223593-04-2

    Catalog No. EBD1318229

    CAS 223593-04-2

    Name (2S)-2-amino-3-(4-carbamoylphenyl)propanoic acid

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    Basic Information

    Synonyms: L-Phenylalanine,4-(aminocarbonyl)- L-PHE(4-C(O)NH2) L-4-CARBAMOYLPHE L-4-CARBAMOYLPHENYLALANINE (2S)-2-amino-3-(4-carbamoylphenyl)propanoicacid

    Molecular Formula: C10H12N2O3

    Molecular Weight: 208.21

    Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

    Product Description:
    (2S)-2-amino-3-(4-carbamoylphenyl)propanoic acid, also known as L-4-Carbamoylphenylalanine, is a non-natural aromatic amino acid derivative. It is a white to off-white crystalline powder with a molecular formula of C10H12N2O3. This compound is structurally characterized by a phenylalanine backbone where the phenyl ring is substituted at the para position with a carbamoyl group (-CONH2). This amino acid derivative serves as a key intermediate in the synthesis of various pharmaceutical agents. Its primary and most significant application is in the research and development of drugs targeting the central nervous system. Specifically, it is a crucial building block for the synthesis of safinamide, a selective and reversible monoamine oxidase B (MAO-B) inhibitor used in the treatment of Parkinson's disease. The (2S)-stereochemistry is essential for its biological activity and incorporation into the final drug molecule. As a specialized, non-proteinogenic amino acid, it is not a general-purpose synthesis reagent but a high-value intermediate with a defined therapeutic application. It is typically handled under controlled conditions in research and GMP manufacturing settings for active pharmaceutical ingredient (API) production.
    Physical Properties
    mg g kg ml l t