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    22190-33-6

    Catalog No. EBD46006

    CAS 22190-33-6

    Name 5-Bromoindoline

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    Basic Information

    Synonyms: 5-Bromoindoline 5-bromo-2,3-dihydroindole indoline,5-bromo-(6ci,8ci)

    Molecular Formula: C8H8BrN

    Molecular Weight: 198.06

    MDL Number: MFCD00027410

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    5-Bromoindoline is an organic compound featuring an indoline core structure substituted with a bromine atom at the 5-position. It is a versatile and valuable building block in synthetic organic chemistry, particularly in the pharmaceutical sector. Its primary application is as a key intermediate in the synthesis of various biologically active molecules. The bromine atom serves as a reactive handle for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), enabling the introduction of diverse substituents onto the indoline scaffold. This makes it crucial for constructing complex heterocyclic compounds, including potential drug candidates targeting central nervous system disorders, serotonin receptors, and other therapeutic areas. As a halogenated heterocycle, it is a fundamental reagent for medicinal chemistry research and the development of new chemical entities. Its utility stems from the combination of the privileged indoline structure and the versatile bromo functionality.
    Physical Properties

    Melting Point: 36-40 °C(lit.)

    Boiling Point: 114-115°C 5mm

    Flash Point: >230 °F

    Density: 1.514 g/cm3

    Storage: −20°C

    Analytical Data

    Appearance: White to brown low melting solid

    mg g kg ml l t