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    221006-71-9

    Catalog No. EBD212443

    CAS 221006-71-9

    Name 4-Bromo-2-methylphenylboronic acid

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    Basic Information

    Synonyms: 4-Bromo-2-methylphenylboronicacid

    Molecular Formula: C7H8BBrO2

    Molecular Weight: 214.85

    Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

    Product Description:
    4-Bromo-2-methylbenzeneboronic acid is an organoboron compound featuring both a boronic acid group and a bromine substituent on a methylated benzene ring. This bifunctional structure makes it a versatile building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. The boronic acid group acts as a key coupling partner with aryl or vinyl halides, while the bromine atom can serve as a handle for further functionalization via subsequent cross-couplings or nucleophilic substitutions. Its primary application is as a synthetic intermediate in the pharmaceutical and materials science industries. It is frequently employed in the construction of complex molecules, including active pharmaceutical ingredients (APIs) and advanced materials. For instance, it has been used in the synthesis of compounds with potential biological activity and in the development of organic electronic materials. The methyl group can influence the electronic properties and steric profile of the resulting coupled products. As a typical arylboronic acid, it is generally air- and moisture-sensitive, requiring storage under inert atmosphere. It is a solid at room temperature and should be handled with standard laboratory safety precautions for organoboron reagents.
    Physical Properties
    mg g kg ml l t