Potassium oxonate, CAS No. 2207-75-2

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2207-75-2

Catalog No. EBD50861

CAS 2207-75-2

Name Potassium oxonate

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Basic Information

Synonyms: oxonicacidpotassiumsalt oteracilpotassium LABOTEST-BBLT00138090 ALLANTOXANICACIDPOTASSIUMSALT 1,4,5,6-tetrahydro-4,6-dioxo-s-triazine-2-carboxylicacid,potassiumsalt 5-azaoroticacid,potassiumsalt kox potassiumazaorotate potassiumoxonate POTASSIUM4,6-DIHYDROXY-1,3,5-TRIAZINE-2-CARBOXYLATE Potassium1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazine-2-carboxylate POTASSIUMALLANTOXANATE 4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylicacid potassium4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylate Potassiumoxonate(OXO) 4,6-Dihydroxy-1,3,5-triazine-2-carboxylicacidpotassiumsalt 1,4,5,6-tetrahydro-4,6-d

Molecular Formula: C4H2KN3O4

Molecular Weight: 195.17

MDL Number: MFCD00010565

Categories: Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents Medicinal Chemistry > Biochemicals and Life Science Reagents > Other Biochemicals and Life Science Reagents

Product Description:

Potassium oxonate is a pyrimidine derivative, specifically the potassium salt of oxonic acid. It is a white to off-white crystalline powder. Its primary and well-defined application is in oncology as a component of the chemotherapeutic regimen S-1 (also known as Teysuno or TS-1). In this combination therapy, potassium oxonate functions as a biochemical modulator to reduce the gastrointestinal toxicity (particularly diarrhea) associated with the active drug 5-fluorouracil (5-FU) and its prodrug tegafur. The mechanism involves the local inhibition of the enzyme orotate phosphoribosyltransferase (OPRT) in the gastrointestinal tract, which prevents the activation of 5-FU into its toxic metabolites in these tissues, thereby sparing the patient from severe side effects while maintaining systemic antitumor efficacy. Beyond its clinical use, potassium oxonate is also employed as a research tool in life science studies. It is commonly used in animal models to induce hyperuricemia by inhibiting uricase, making it valuable for research on gout, renal disease, and metabolic disorders.

Physical Properties

Melting Point: 300 °C(lit.)

Analytical Data

Appearance: off-white solid