Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

    OK
    Get Quote Login
    220210-56-0

    Catalog No. EBD1984781

    CAS 220210-56-0

    Name 3-tert-Butoxycarbonylphenylboronic acid

    Get Quote
    Basic Information

    Synonyms: 3-(tert-Butoxycarbonyl)phenylboronicacid 3-tert-Butoxycarbonylphenylboronicacid

    Molecular Formula: C11H15BO4

    Molecular Weight: 222.05

    MDL Number: MFCD01630855

    Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

    Product Description:
    3-(tert-Butoxycarbonyl)benzeneboronic acid is an organoboron compound featuring a benzene ring substituted with a boronic acid group and a tert-butoxycarbonyl (Boc) protecting group. The boronic acid moiety enables it to participate in key cross-coupling reactions, most notably the Suzuki-Miyaura reaction, which is fundamental for constructing biaryl and other carbon-carbon bonds. The Boc group serves as a widely used protecting group for amines, making this compound a versatile bifunctional building block. Its primary application is in medicinal chemistry and pharmaceutical research as a key synthetic intermediate. It is frequently employed in the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and drug candidates. The presence of both reactive handles allows for sequential and selective functionalization, facilitating the construction of diverse molecular scaffolds. This compound is particularly valuable for introducing a Boc-protected aniline or benzoic acid derivative into a target structure after deprotection. As a commercial product, it is typically supplied as a white to off-white solid and requires storage under inert conditions to maintain stability. It is a standard reagent in the toolkit of synthetic organic chemists working on drug discovery and development projects.
    Physical Properties

    Melting Point: 96-102°C

    Boiling Point: 375 °C at 760 mmHg

    Flash Point: 180.6 °C

    Density: 1.15 g/cm3

    Storage: Keep Cold

    Analytical Data

    Appearance: white to light yellow crystal powder

    mg g kg ml l t