2,3-Dihydrobenzo[b][1,4]dioxin-6-amine, CAS No. 22013-33-8

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22013-33-8

Catalog No. EBD39682

CAS 22013-33-8

Name 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine

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Basic Information

Synonyms: 6-Amino-1,4-benzodioxane 3,4-ETHYLENDIOXYANILINE 3,4-ETHYLENEDIOXYANILINE 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine 1,4-Benzodioxan-6-amine 1,4-benzodioxan-6-ylamine

Molecular Formula: C8H9NO2

Molecular Weight: 151.16

MDL Number: MFCD00006824

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

6-Amino-1,4-benzodioxane is an organic compound featuring a benzodioxane core structure substituted with an amino group at the 6-position. It is a versatile heterocyclic amine building block. This compound is primarily utilized as a key intermediate in pharmaceutical research and synthesis. Its structure serves as a privileged scaffold for developing biologically active molecules. It has been investigated in the synthesis of compounds targeting various receptors, including potential applications in central nervous system (CNS) drug discovery, such as α-adrenergic receptor ligands. As a bifunctional molecule containing both an amine group and a benzodioxane ring, it is a valuable synthon in organic chemistry for constructing more complex heterocyclic systems and pharmacophores through reactions like amide coupling, reductive amination, and nucleophilic substitution.

Physical Properties

Melting Point: 29-31 °C(lit.)

Boiling Point: 116-118°C 3mm

Flash Point: 113 °C

Density: 1.231 g/mL(lit.)

Solubility: insoluble

Refractivity: n20/D 1.599(lit.)

Analytical Data

Appearance: brown to black viscous liquid after melting