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    218301-22-5

    Catalog No. EBD8781

    CAS 218301-22-5

    Name 2-Fluoro-5-formylbenzonitrile

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    Basic Information

    Synonyms: 3-Cyano-4-fluorobenzaldehyde 2-Fluoro-5-Formyl-benzonitrile Benzonitrile,2-fluoro-5-formyl- 2-Fluoro-5-formylbenzonitrile

    Molecular Formula: C8H4FNO

    Molecular Weight: 149.12

    MDL Number: MFCD01863558

    Categories: Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones Synthetic Chemistry > Organic Building Blocks > Cyano Compounds

    Product Description:
    2-Fluoro-5-formylbenzonitrile is an aromatic compound featuring both a formyl (aldehyde) group and a nitrile (cyano) group on a fluorinated benzene ring. This structure makes it a versatile bifunctional building block in organic synthesis. Its primary application is as a key intermediate in the synthesis of various heterocyclic compounds and active pharmaceutical ingredients (APIs). The aldehyde group is highly reactive, allowing for condensation reactions (e.g., to form imines or undergo nucleophilic addition), while the nitrile group can be hydrolyzed to carboxylic acids or reduced to amines. The fluorine atom can influence the electronic properties and metabolic stability of the final molecules. It is commonly used in medicinal chemistry research for constructing drug-like scaffolds. This compound is a valuable reagent for constructing complex molecules in research settings, particularly in the development of kinase inhibitors and other biologically active small molecules. It should be handled with care as it may cause skin and eye irritation.
    Physical Properties

    Melting Point: 80-84 °C(lit.)

    Boiling Point: 215.603 °C at 760 mmHg

    Flash Point: 84.194 °C

    Density: 1.26 g/cm3

    mg g kg ml l t