D-Ethylgonendione, CAS No. 21800-83-9

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21800-83-9

Catalog No. EBD2199017

CAS 21800-83-9

Name D-Ethylgonendione

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Basic Information

Synonyms: 18-Methyl-estr-4-ene-3,17-dione 13-Ethyl-gon-4-ene-3,17-dione (8R,9S,10R,14S)-13-Ethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione (8R,9S,10R,14S)-13-ethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione(non-preferredname) (8R,9S,10R,13S,14S)-13-ethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione(non-preferredname) D-Ethylgonendione

Molecular Formula: C19H26O2

Molecular Weight: 286.41

Categories: Medicinal Chemistry > APIs and Their Salts > Endocrine & Metabolic Drugs Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates

Product Description:

18-Methyl-4-estrene-3,17-dione is a synthetic steroid derivative. It is structurally characterized as a 19-nor steroid with a methyl group at the C-18 position, featuring a 4-ene-3,17-dione core. This compound is a key chiral intermediate in the synthesis of various steroidal pharmaceuticals. Its primary and most significant application is in the industrial synthesis of potent anabolic-androgenic steroids (AAS) and progestins. It serves as a crucial precursor in the manufacturing of compounds such as nandrolone (19-nortestosterone) and its esters (e.g., nandrolone decanoate), as well as the progestin norethisterone (norethindrone). These APIs are used clinically for conditions like anemia, breast cancer, and as components of hormonal contraceptives and hormone replacement therapy. As a steroid synthon, its value lies in its defined stereochemistry and functional groups, which allow for efficient chemical transformations into target drug molecules. Handling requires caution due to its hormonal activity and potential health effects associated with steroid intermediates.

Physical Properties

Melting Point: 1676-1670C

Boiling Point: 445.2 °C at 760 mmHg

Flash Point: 166 °C

Density: 1.11 g/cm3

Analytical Data

Appearance: Light yellow crystalline solid