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    21651-84-3

    Catalog No. EBD3610793

    CAS 21651-84-3

    Name Cyclohexanol, 2-(methylamino)-, (1S,2S)-

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    Basic Information

    Synonyms: Cyclohexanol,2-(methylamino)-,(1S,2S)-

    Molecular Formula: C7H15NO

    Molecular Weight: 129.2

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (1S,2S)-2-(Methylamino)cyclohexan-1-ol is a chiral amino alcohol compound characterized by a cyclohexane ring substituted with both a hydroxyl group and a methylamino group in a trans configuration. Its specific stereochemistry, defined by the (1S,2S) absolute configuration, makes it a valuable chiral building block and ligand precursor in asymmetric synthesis. This compound serves as a key chiral intermediate in the synthesis of various pharmaceuticals. Its primary application is in the preparation of chiral ligands, such as derivatives of 1,2-diaminocyclohexane, which are widely used in asymmetric hydrogenation and other enantioselective catalytic reactions. These reactions are crucial for producing active pharmaceutical ingredients (APIs) with high enantiomeric purity, particularly in the fields of cardiovascular and central nervous system drugs. As a bifunctional molecule containing both amine and alcohol groups, it is also employed in the synthesis of other complex chiral molecules and as a precursor for resolving agents. Its utility stems from the rigidity of the cyclohexane ring and the defined spatial orientation of its functional groups, which are essential for inducing stereoselectivity in chemical transformations.
    Physical Properties
    mg g kg ml l t