2-(4-Aminophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, CAS No. 214360-73-3

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

214360-73-3

Catalog No. EBD1957941

CAS 214360-73-3

Name 2-(4-Aminophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Get Quote

Basic Information

Synonyms: 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine 2-(4-Aminophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 4-Aminobenzeneboronicacidpinacolester 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenamine 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (4-Aminophenyl)boronicacid,pinacolester 4-Aminophenylboronicacidpinacolester

Molecular Formula: C12H18BNO2

Molecular Weight: 219.09

MDL Number: MFCD02093721

Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

4-Aminophenylboronic acid pinacol ester is an organoboron compound featuring both an aromatic amine group and a protected boronic acid moiety. The pinacol ester group stabilizes the boronic acid, making it a versatile and air-stable building block for various synthetic transformations. This compound is a key intermediate in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing biaryl and heterobiaryl systems. Its primary application lies in pharmaceutical research and development, where it is extensively used to synthesize drug candidates and active pharmaceutical ingredients (APIs). The aromatic amine group provides a handle for further functionalization, making it a valuable synthon for constructing complex molecules with potential biological activity. As a stable and commercially available boronic ester, it is a fundamental reagent in medicinal chemistry and materials science for creating libraries of compounds. Standard safety precautions for handling organic compounds should be observed.

Physical Properties

Melting Point: 165-169 °C(lit.)

Boiling Point: 340 °C at 760 mmHg

Flash Point: 159.4 °C

Density: 1.05 g/cm3

Solubility: Insoluble

Storage: Refrigerator (+4°C)

Analytical Data

Appearance: almost white to light beige crystalline powder