2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, CAS No. 214360-48-2

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

214360-48-2

Catalog No. EBD39491

CAS 214360-48-2

Name 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

Get Quote

Basic Information

Synonyms: 2-Cyanobenzeneboronicacidpinacolester 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzolcarbonitril 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile Benzonitrile,2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 2-Cyanobenzeneboronicacid,pinacolester 2-Cyanophenylboronicacid,pinacolester 2-Cyanophenylboronicacidpinacolester

Molecular Formula: C13H16BNO2

Molecular Weight: 229.08

MDL Number: MFCD04038747

Categories: Synthetic Chemistry > Organic Building Blocks > Cyano Compounds Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

Product Description:

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is a bifunctional organoboron compound featuring a pinacol boronate ester (BPin) group directly attached to a benzonitrile ring. The BPin moiety serves as a stable, versatile handle for Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds with aryl or vinyl halides. This compound is widely utilized as a key building block in medicinal chemistry for the synthesis of biaryl structures, which are prevalent in drug candidates targeting kinases, GPCRs, and other therapeutic targets. The nitrile group can be further transformed into amides, amines, or tetrazoles, enhancing its utility in late-stage functionalization. In addition to pharmaceutical research, it is employed in the development of organic electronic materials and agrochemical intermediates. Its high stability and compatibility with diverse reaction conditions make it a standard reagent in both academic and industrial synthetic laboratories.

Physical Properties

Melting Point: 85-90 °C

Boiling Point: 357.1 °C at 760 mmHg

Flash Point: 169.8 °C

Density: 1.06g/cm3