1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione, CAS No. 2140-76-3

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2140-76-3

Catalog No. EBD44658

CAS 2140-76-3

Name 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

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Basic Information

Synonyms: 2'-O-methyluridine -2'-O-METHYLURIDINE 2'-O-METHYLURIDINE(CHIRAL) 2''-O-METHYLURIDINECRYSTALLINE 1-[(2r,3r,4r,5r)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone 1-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidine-2,4-dione 1-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Molecular Formula: C10H14N2O6

Molecular Weight: 258.23

MDL Number: MFCD00056054

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

2'-Methoxyuridine is a chemically modified nucleoside derivative where a methoxy group replaces the hydroxyl group at the 2' position of the ribose sugar. This structural alteration imparts unique properties compared to its natural counterpart, uridine. This compound serves as a crucial building block in nucleic acid chemistry and medicinal chemistry research. Its primary application is in the synthesis of modified oligonucleotides, particularly for antisense and siRNA technologies, where the 2'-O-methyl modification enhances nuclease resistance and improves the stability and efficacy of therapeutic oligonucleotides. It is also used in the study of RNA structure, function, and as a precursor for the synthesis of various antiviral and anticancer nucleoside analogs. As a specialty nucleoside, it is a valuable intermediate for probing biochemical pathways and developing novel therapeutic agents targeting RNA-related processes.

Physical Properties

Melting Point: 154-156 ºC

Density: 1.536 g/cm3

Storage: Store at 0°C

Analytical Data

Appearance: White solid