2'-O-Methylguanosine, CAS No. 2140-71-8

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2140-71-8

Catalog No. EBD22756

CAS 2140-71-8

Name 2'-O-Methylguanosine

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Basic Information

Synonyms: 1-Methylguanosine=2-O-Methylguanosine 2'-OMe-G 2'-O-Methylguanosine 2'-o-methyl-d-guanosine 2-amino-9-[(2r,3r,4r,5r)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]-3h-purin-6-one 2-amino-9-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3h-purin-6-one 2-azanyl-9-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]-3h-purin-6-one 2'-omeguanosine

Molecular Formula: C11H15N5O5

Molecular Weight: 297.27

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

2'-Methoxyguanosine is a modified nucleoside where a methoxy group replaces the hydroxyl group at the 2' position of the ribose sugar. This structural alteration distinguishes it from the canonical nucleoside guanosine. It is a solid compound with specific physicochemical properties relevant to biochemical research. This compound serves as a crucial building block and reference standard in nucleic acid chemistry and medicinal chemistry. Its primary application is in the study of RNA structure, function, and metabolism, particularly in investigating the effects of sugar modifications on RNA stability and biological activity. It is used as an intermediate in the synthesis of more complex nucleoside analogs and oligonucleotides for potential therapeutic applications, including antiviral and anticancer drug discovery. As a modified nucleoside, 2'-Methoxyguanosine is handled as a research chemical for laboratory use only. It is not intended for diagnostic or therapeutic purposes. Proper safety protocols should be followed when handling this material.

Physical Properties

Melting Point: 227-231°C (dec.)

Boiling Point: 711.724 °C at 760 mmHg

Flash Point: 384.237 °C

Density: 1.983 g/cm3

Analytical Data

Appearance: White solid