4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one, CAS No. 2140-61-6

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2140-61-6

Catalog No. EBD164171

CAS 2140-61-6

Name 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one

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Basic Information

Synonyms: 5-methylcytidine 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidin-2-one 5-methylcytidine,98.0+%(lc)(t) cytidine,5-methyl- 3:pn:us20060035254page:63claimedsequence nsc363933 5-me-cr 4-amino-5-methyl-1-pentofuranosylpyrimidin-2(1H)-one 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidin-2-one 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one

Molecular Formula: C10H15N3O5

Molecular Weight: 257.24

MDL Number: MFCD00006548

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

5-Methylcytidine is a modified nucleoside where a methyl group is attached to the 5-position of the cytosine base. It is a naturally occurring derivative of cytidine and serves as a fundamental building block in RNA biochemistry and molecular biology research. Its primary applications are in life science research. It is used as a substrate for studying RNA modification enzymes, particularly methyltransferases, and in the synthesis of modified oligonucleotides. These modified oligonucleotides are crucial tools for investigating RNA structure, function, and stability, as well as for developing diagnostic probes and potential therapeutic agents targeting RNA. It is also a key intermediate in the synthesis of more complex nucleoside analogs with pharmaceutical interest. As a modified nucleoside, it is not a typical, high-volume synthetic building block for general organic synthesis. Its value and usage are predominantly tied to its specific biological role and its function as a specialized precursor in nucleotide chemistry.

Physical Properties

Melting Point: 212-215 °C (dec.)(lit.)

Boiling Point: 537.5 °C at 760 mmHg

Flash Point: 278.9 °C

Density: 1.79 g/cm3

Refractivity: 15 ° (C=2, H2O)