ent-6-methoxy-10-methyl-galanthaman-32-ol, CAS No. 21133-52-8

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21133-52-8

Catalog No. EBD14012

CAS 21133-52-8

Name ent-6-methoxy-10-methyl-galanthaman-32-ol

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Basic Information

Synonyms: LycoramineBase Dihydrogalanthamine 1,2-Dihydrogalanthamine (4aS,6S,8aS)-4a,5,7,8,9,10,11,12-Octahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol LycoramineHydrobromide ent-6-methoxy-10-methyl-galanthaman-32-ol Dihydroepigalanthamin

Molecular Formula: C17H23NO3

Molecular Weight: 289.38

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > Biochemicals and Life Science Reagents > Phytochemicals and Natural Products

Product Description:

Dihydrogalanthamine is a natural alkaloid derivative of galanthamine, which is primarily isolated from plants of the Amaryllidaceae family. It shares a similar tetracyclic ring structure with galanthamine, featuring a fused benzofuran and azepine core. This compound is a potent and selective acetylcholinesterase (AChE) inhibitor. Its primary application is in the research and development of therapeutic agents for neurodegenerative diseases, most notably Alzheimer's disease. By inhibiting AChE, it increases the concentration of acetylcholine in the synaptic cleft, thereby enhancing cholinergic neurotransmission, which is crucial for memory and cognitive functions. As a natural product derivative, dihydrogalanthamine serves as a key intermediate in the synthesis and structural modification of galanthamine-based drugs. It is also an important reference standard in pharmacological studies and for the quality control of related pharmaceutical preparations.

Physical Properties

Melting Point: 122-124°C

Boiling Point: 436.4°C at 760 mmHg

Flash Point: 217.7°C

Density: 1.25 g/cm3