2-(1-Piperazinyl)pyrimidine dihydrochloride, CAS No. 20980-22-7

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20980-22-7

Catalog No. EBD2201970

CAS 20980-22-7

Name 2-(1-Piperazinyl)pyrimidine dihydrochloride

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Basic Information

Synonyms: 2-(1-Piperazinyl)pyrimidinedihydrochloride 2-(1-Piperazino)pyrimidine N-(2-Pyrimidinyl)-piperazine 2-piperazino-pyrimidine N-(2-Pyrimidyl)piperazine 1-(2-pyrimimidinyl)piperazine 2-(piperazin-1-yl)pyrimidine 4-pyrimidin-2-ylpiperazin-1-ium

Molecular Formula: C8H12N4

Molecular Weight: 164.21

MDL Number: MFCD00012779

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

1-(2-Pyrimidinyl)piperazine is a heterocyclic organic compound featuring a piperazine ring linked to a pyrimidine ring. It serves as a versatile and important building block in medicinal chemistry. Its primary and most significant application is as a key intermediate in the synthesis of various pharmaceutical agents. Notably, it is a crucial precursor in the production of the atypical antipsychotic drug Aripiprazole, where it forms part of the core molecular structure. The compound's bifunctional nature, containing both a basic piperazine nitrogen and a pyrimidine ring, makes it valuable for constructing molecules with specific biological activities, particularly targeting the central nervous system. Beyond its role as a dedicated pharmaceutical intermediate, 1-(2-pyrimidinyl)piperazine is also recognized as a valuable synthetic building block for constructing more complex heterocyclic systems and amine-containing compounds in organic synthesis and drug discovery research.

Physical Properties

Melting Point: 32-34°C

Boiling Point: 277 °C(lit.)

Flash Point: >110 °C

Density: 1.158 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.587(lit.)

Analytical Data

Appearance: clear yellow liquid after melting