1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine, CAS No. 207857-15-6

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207857-15-6

Catalog No. EBD213686

CAS 207857-15-6

Name 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine

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Basic Information

Synonyms: 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine tert-butyl{(tert-butoxycarbonyl)[(trifluoromethyl)sulfonyl]carbamimidoyl}carbamate(non-preferredname) carbamicacid,N,N'-[[(trifluoromethyl)sulfonyl]carbonimidoyl]bis-,C,C'-bis(1,1-dimethylethyl)ester -di-boc-n -triflylguanidine -bis(tert-butoxycarbonyl)-n -bis(1,1-dimethylethoxycarbonyl)-n -(trifluoromethylsulfonyl)guanidine -(trifluoromethanesulfonyl)guanidine carbamicacid,[[(trifluoromethyl)sulfonyl]carbonimidoyl]bis-,bis(1,1-dimethylethyl)ester(9ci) N,N'-Bis(tert-butoxycarboyl)-N''-trifylguanidine

Molecular Formula: C12H20F3N3O6S

Molecular Weight: 391.36

MDL Number: MFCD02683528

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Basic Synthetic Reagents > Other Basic Synthetic Reagents

Product Description:

1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine is a specialized guanidine derivative featuring two tert-butoxycarbonyl (Boc) protecting groups and a trifluoromethanesulfonyl (triflyl) group. This compound serves as a versatile and highly reactive synthetic intermediate, primarily utilized in the construction of complex heterocyclic systems, particularly in medicinal chemistry. Its primary application is as a key building block for the synthesis of 2-aminoimidazoles and related heterocyclic scaffolds. The triflyl group acts as an excellent leaving group, enabling efficient nucleophilic substitution reactions with amines to form guanidine linkages. This reactivity is crucial for creating pharmacologically important structures found in various drug candidates, including kinase inhibitors and antimicrobial agents. As a reagent, it facilitates the introduction of protected guanidine moieties under mild conditions. Its stability and defined reactivity profile make it a valuable tool for researchers developing novel bioactive molecules, especially in the areas of oncology and infectious diseases.

Physical Properties

Melting Point: 113 °C (dec.)(lit.)

Density: 1.36g/cm3