HIPPURYL-HIS-LEU FREE BASE, CAS No. 207386-83-2

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207386-83-2

Catalog No. EBD3046633

CAS 207386-83-2

Name HIPPURYL-HIS-LEU FREE BASE

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Basic Information

Synonyms: N-HIPPURYL-HIS-LEUHYDRATE HIPPURYL-HIS-LEUFREEBASE N-BENZOYL-GLY-HIS-LEUHYDRATE N-HIPPURYL-HIS-LEUHYDRATE{99%} HIPPURYL-L-HISTIDYL-L-LEUCINEHYDRATE,99% N-BENZOYLGLYCYL-L-HISTIDYL-L-LEUCINEHYDRATE N-BENZOYL-GLY-HIS-LEU,N-HIPPURYL-L-HISTIDYL-L-LEUCINEHYDRATE L-Leucine,N-benzoylglycyl-L-histidyl-,hydrate(9CI)

Molecular Formula: C21H29N5O6

Molecular Weight: 447.48

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics Medicinal Chemistry > Drug Impurities and Reference Standards > Drug Metabolite References

Product Description:

HIPPURYL-HIS-LEU FREE BASE is a synthetic tripeptide derivative with the sequence N-Hippuryl-L-Histidyl-L-Leucine. It is commonly supplied as a hydrate. This compound is a key substrate and reference standard in biochemical and pharmacological research. Its primary and well-established application is as a substrate for the enzyme angiotensin-converting enzyme (ACE). ACE plays a crucial role in the renin-angiotensin system, regulating blood pressure. This peptide is specifically cleaved by ACE, and the reaction is widely used in vitro to measure and characterize ACE activity. Consequently, it serves as an essential tool for screening and evaluating potential ACE inhibitors, which are a major class of cardiovascular drugs (e.g., captopril, enalapril). It is also used as a reference standard or metabolite analog in related studies. Due to its specific and dedicated role as a biochemical tool and reference material for drug discovery and enzyme studies, it is classified under life science reagents and pharmaceutical reference standards, rather than as a general synthetic building block.

Physical Properties

Color: white to off-white

Melting Point: 108-110 °C (dec.)

Storage: −20°C