2'-C-Methylcytidine, CAS No. 20724-73-6

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20724-73-6

Catalog No. EBD21331

CAS 20724-73-6

Name 2'-C-Methylcytidine

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Basic Information

Synonyms: NM107 cytidine,2'-C-methyl- (3-Aminopropyl)diethoxyethylsilane 2'-C-Methylcytidine

Molecular Formula: C10H15N3O5

Molecular Weight: 257.24

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

2'-C-Methylcytidine is a synthetic nucleoside analogue characterized by a methyl group substitution at the 2' position of the ribose sugar moiety. This structural modification distinguishes it from the natural nucleoside cytidine and imparts specific biochemical properties. Its primary application is in antiviral research, particularly as a key intermediate in the synthesis of more complex nucleoside analogues. For instance, it serves as a crucial building block in the development of prodrugs like sofosbuvir, a direct-acting antiviral agent used to treat hepatitis C virus (HCV) infection. The 2'-methyl modification contributes to the metabolic stability and potency of these therapeutic agents by acting as a chain terminator during viral RNA replication. As a modified nucleoside, it is a valuable tool in biochemistry and medicinal chemistry for studying RNA metabolism and for the design of novel antiviral and anticancer therapeutics. Its use is predominantly confined to research and pharmaceutical development settings.

Physical Properties

Color: white to off-white

Melting Point: 243-245 °C

Boiling Point: 523.9 °C at 760 mmHg

Flash Point: 270.7 °C

Density: 1.72 g/cm3

Storage: −20°C

Analytical Data

Appearance: White to Off-White Powder