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    205448-66-4

    Catalog No. EBD304621

    CAS 205448-66-4

    Name methyl 4-chloro-7-methoxyquinoline-6-carboxylate

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    Basic Information

    Synonyms: methyl4-chloro-7-methoxyquinoline-6-carboxylate methyl4-chloro-7-methoxy-quinoline-6-carboxylate 4-Chloro-7-methoxy-6-methoxycarbonylquinoline

    Molecular Formula: C12H10ClNO3

    Molecular Weight: 251.67

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    4-Chloro-7-methoxy-6-quinolinecarboxylic acid methyl ester is a key heterocyclic organic compound featuring a quinoline core substituted with chloro, methoxy, and methyl ester functional groups. It serves as a crucial synthetic intermediate in medicinal chemistry. Its primary and most significant application is in the synthesis of targeted anticancer drugs, particularly tyrosine kinase inhibitors. This compound is a vital building block for the production of Cabozantinib (XL184), a multi-kinase inhibitor approved for the treatment of medullary thyroid cancer and advanced renal cell carcinoma. The quinoline scaffold and its specific substitution pattern are essential for the drug's biological activity and binding affinity. As a specialized heterocyclic intermediate with a defined and high-value application in API manufacturing, it is categorized primarily within pharmaceutical intermediates. Its well-defined structure also qualifies it as a specific organic synthesis building block for constructing complex drug molecules.
    Physical Properties
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