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    204580-28-9

    Catalog No. EBD328721

    CAS 204580-28-9

    Name N-(2-(tert-butyldimethylsilyloxy)ethyl)methylamine

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    Basic Information

    Synonyms: N-(2-(tert-butyldimethylsilyloxy)ethyl)methylamine 2-(tert-butyldimethylsilyloxy)-N-methylethanamine 2-(tert-butyldimethylsiloxy)-N-methylethylamine (2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)methylamine

    Molecular Formula: C9H23NOSi

    Molecular Weight: 189.37

    Categories: Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Basic Synthetic Reagents > Protecting and Deprotecting Reagents

    Product Description:
    N-[2-(tert-Butyldimethylsilyloxy)ethyl]methylamine is a bifunctional organic compound featuring both a primary amine group and a tert-butyldimethylsilyl (TBDMS) ether-protected hydroxyl group. This structure makes it a versatile building block and reagent in synthetic organic chemistry. Its primary application is as a protected amino alcohol synthon. The amine group can participate in amide bond formation or act as a nucleophile, while the TBDMS-protected hydroxyl group provides stability during various synthetic transformations and can be selectively deprotected under mild acidic conditions (e.g., using tetra-n-butylammonium fluoride, TBAF) when needed. This compound is particularly useful in the synthesis of complex molecules, including pharmaceuticals and bioactive compounds, where the introduction of a 2-(methylamino)ethanol moiety is required. As a specialty amine and silyl ether, it serves as a valuable intermediate for constructing molecular scaffolds and for use in medicinal chemistry research. It is typically handled under inert atmosphere due to the sensitivity of the amine group and stored under cool, dry conditions.
    Physical Properties
    mg g kg ml l t