(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid hydrate, CAS No. 204251-24-1

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

204251-24-1

Catalog No. EBD2221860

CAS 204251-24-1

Name (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid hydrate

Get Quote

Basic Information

Synonyms: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoicacidhydrate Fmoc-L-Glutamicacid-O-tert-butylesterhydrate N-Fmoc-L-glutamicacidgamma-tert-butylestermonohydrate N-(9-Fluorenylmethoxycarbonyl)-L-glutamicacid-O-tert-butylestermonohydrate (2S)-5-tert-butoxy-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-oxopentanoicacidhydrate(non-preferredname) (2S)-5-tert-butoxy-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-oxopentanoate Fmoc-L-Glu(OtBu)-OHHydrate Fmoc-Glu(OtBu)-OH·H2O Fmoc-Glu(tBu)-OH·H2O Fmoc-Glu(Otbu)-OhH2O FMOC-L-GLUTAMIC?ACID?O-TERT-BUTYL?ESTER?MONOHYDRATE FMOC-L-GLUTAMICACIDO-TERT-BUTYLESTERMONOHYDRATE

Molecular Formula: C24H29NO7

Molecular Weight: 443.49

MDL Number: MFCD00150485

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

Fmoc-L-glutamic acid 1-tert-butyl ester monohydrate is a protected amino acid derivative widely used in solid-phase peptide synthesis (SPPS). Its chemical structure features an L-glutamic acid core with two orthogonal protecting groups: the N-terminal amine is protected by a base-labile 9-fluorenylmethoxycarbonyl (Fmoc) group, while the γ-carboxylic acid side chain is protected by an acid-labile tert-butyl (OtBu) ester. This protection scheme allows for the selective deprotection and sequential coupling of amino acids during peptide chain assembly. This compound serves as a crucial building block for introducing glutamic acid residues into synthetic peptides. The protected side chain is essential for preventing unwanted side reactions during synthesis. It is a fundamental reagent in the production of therapeutic peptides, peptide hormones, and research peptides where glutamic acid's role in structure, function, or as a site for further modification (e.g., conjugation) is required. The monohydrate form ensures stability and consistent handling.

Physical Properties

Melting Point: 86-89 °C(lit.)

Boiling Point: 633.5 °C at 760 mmHg

Flash Point: 336.9 °C

Storage: 2-8°C

Analytical Data

Appearance: white fine powder