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    20289-27-4

    Catalog No. EBD953058

    CAS 20289-27-4

    Name 7-phenylmethoxyindole

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    Basic Information

    Synonyms: 7-benzyloxyindolecrystalline 7-Benzyloxy-1H-indole 7-phenylmethoxyindole 7-(Benzyloxy)indole 7-(benzyloxy)-1H-indole 7-(phenylmethoxy)indole 7-benzyloxy-indole

    Molecular Formula: C15H13NO

    Molecular Weight: 223.27

    MDL Number: MFCD00037974

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    7-Benzyloxyindole is an organic compound featuring an indole core substituted with a benzyloxy group at the 7-position. It serves as a versatile and valuable synthetic building block in medicinal chemistry and organic synthesis. Its primary application is as a key intermediate in the synthesis of more complex indole derivatives, particularly those with potential biological activity. The benzyloxy group acts as a common protecting group for phenolic hydroxyls, which can be selectively removed under specific conditions. This makes 7-benzyloxyindole a crucial precursor for generating 7-hydroxyindole scaffolds, which are found in various pharmacologically active molecules and natural products. As a specialized heterocyclic intermediate, it is used in research and development for constructing drug candidates, especially in the areas of central nervous system (CNS) agents and serotonin receptor modulators. Its utility stems from the reactivity of the indole nitrogen and the 3-position, allowing for further functionalization to create diverse chemical libraries for biological screening.
    Physical Properties

    Melting Point: 70-74 °C

    Boiling Point: 411.6 °C at 760 mmHg

    Flash Point: 148.9 °C

    Density: 1.196 g/cm3

    Storage: −20°C

    Analytical Data

    Appearance: Off-white crystalline powder

    mg g kg ml l t