(S)-2-((4-((3-Fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonate, CAS No. 202825-46-5

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202825-46-5

Catalog No. EBD22630

CAS 202825-46-5

Name (S)-2-((4-((3-Fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonate

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Basic Information

Synonyms: (S)-2-((4-((3-Fluorobenzyl)oxy)benzyl)amino)propanamidemethanesulfonate 2(S)-[4-(3-Fluorobenzyloxy)benzylamino]propionamidemethanesulfonate Safinamidemesilate FCE-28073(R-isomer) PNU-151774E NW-1015 FCE-26743 N~2~-{4-[(3-fluorobenzyl)oxy]benzyl}-D-alaninamidemethanesulfonate Safinamidemesylate Safinamide Mesylate

Molecular Formula: C18H23FN2O5S

Molecular Weight: 398.45

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > Drug Impurities and Reference Standards > Impurity Standards

Product Description:

Safinamide mesylate is the mesylate salt form of safinamide. It is a highly selective and reversible monoamine oxidase B (MAO-B) inhibitor. The compound is characterized by its α-aminoamide structure, which incorporates a benzyloxy moiety. Safinamide mesylate is the active pharmaceutical ingredient (API) used in the treatment of Parkinson's disease. It is administered as an adjunct therapy to levodopa/carbidopa in patients experiencing "off" episodes. Its dual mechanism of action involves not only MAO-B inhibition, which increases dopamine levels in the brain, but also modulation of glutamate release via state- and use-dependent sodium channel blockade. As a commercial drug substance, safinamide mesylate is subject to strict pharmacopoeial standards (e.g., USP, EP). Consequently, related substances and process impurities of safinamide are critical for quality control, making safinamide mesylate and its derivatives important as reference standards and impurity markers in pharmaceutical analysis.

Physical Properties

Color: white to tan

Boiling Point: 476.7°Cat760mmHg

Flash Point: 242.1°C

Storage: 2-8°C

Safety Information

Packing Level: III

Hazard Category: 6.1

Transport Codes: 2811