N6-Methyl-2'-deoxyadenosine, CAS No. 2002-35-9

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2002-35-9

Catalog No. EBD46402

CAS 2002-35-9

Name N6-Methyl-2'-deoxyadenosine

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Basic Information

Synonyms: N-6-methyl-2-deoxyadenosine N(6)-Methyl-2'-deoxyadenosine 2'-Deoxy-N(6)-methyladenosine N(6)-Me-Dado NSC66392 Adenosine,2'-deoxy-N-methyl- 2'-deoxy-N-methyladenosine N6-Methyl-2'-deoxyadenosine N6-Methyl-2'-Deoxy-Adenosine 2'-deoxy-n6-methyl-d-adenosine 2''-deoxy-n6-methyladenosine (2r,3s,5r)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol (2r,3s,5r)-5-[6-(methylamino)purin-9-yl]-2-methylol-tetrahydrofuran-3-ol n6-me-da 2'-deoxy-n6-methyladenosine

Molecular Formula: C11H15N5O3

Molecular Weight: 265.27

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

N6-Methyl-2'-deoxyadenosine is a modified nucleoside where a methyl group is attached to the exocyclic amino group (N6 position) of the adenine base in a 2'-deoxyribose sugar framework. This structural modification makes it a key analog of the natural nucleoside 2'-deoxyadenosine. This compound serves as a crucial biochemical tool and research reagent. It is primarily used in studies related to DNA methylation, epigenetics, and nucleic acid biochemistry. As a modified nucleoside, it can be incorporated into oligonucleotides to investigate the effects of N6-methyladenine (6mA) modifications in DNA, a topic of significant interest in epigenetic regulation beyond the traditional focus on 5-methylcytosine. It is also a valuable intermediate in the synthesis of more complex nucleoside analogs with potential therapeutic applications. Its availability as a high-purity standard makes it essential for analytical purposes, such as serving as a reference compound in liquid chromatography-mass spectrometry (LC-MS) for the detection and quantification of modified nucleosides in biological samples.

Physical Properties

Boiling Point: 603.6 °C at 760 mmHg

Flash Point: 318.8 °C

Density: 1.72 g/cm3

Storage: −20°C