2-Fluorophenylboronic acid, CAS No. 1993-03-9

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1993-03-9

Catalog No. EBD222798

CAS 1993-03-9

Name 2-Fluorophenylboronic acid

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Basic Information

Synonyms: 2-Flurorphenylboronicacid akosbrn-0104 o-fluorophenylboronicacid rarechemahpb0215 2-fluorophenylboronic 2-fluorobenzeneboronicacid97% 2-Fluorophenylboronicacid 2-fluorobenzeneboronicacid boronicacid,(2-fluorophenyl)-(9ci) benzeneboronicacid,o-fluoro-(7ci,8ci)

Molecular Formula: C6H6BFO2

Molecular Weight: 139.92

Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

2-Fluorophenylboronic acid is an organoboron compound characterized by a phenyl ring substituted with a fluorine atom at the ortho position and a boronic acid (-B(OH)₂) functional group. It is a white to off-white crystalline powder and serves as a versatile building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. Its primary application is as a key synthetic intermediate in the pharmaceutical and agrochemical industries. The presence of the fluorine atom, which can modulate the electronic properties, lipophilicity, and metabolic stability of target molecules, makes this compound valuable for constructing complex bioactive molecules. It is frequently employed in the synthesis of drug candidates, including potential kinase inhibitors and other therapeutic agents. As a boronic acid derivative, it requires careful handling and storage under inert conditions to prevent protodeboronation and maintain reactivity. It is a commercially available reagent widely used in research and development for constructing biaryl and heterobiaryl scaffolds central to modern medicinal chemistry.

Physical Properties

Melting Point: 101-110 °C(lit.)

Boiling Point: 267.8 °C at 760 mmHg

Flash Point: 115.8 °C

Density: 1.24 g/cm3

Storage: 0-6°C

Analytical Data

Appearance: white to light yellow crystalline powder