(S)-1-Boc-3-(Aminomethyl)pyrrolidine, CAS No. 199175-10-5

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199175-10-5

Catalog No. EBD2219040

CAS 199175-10-5

Name (S)-1-Boc-3-(Aminomethyl)pyrrolidine

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Basic Information

Synonyms: (s)-1-boc-3-aminomethylpyrrolidine (s)-1-n-boc-3-(aminomethyl)pyrrolidine (s)-3-(aminomethyl)-1-n-boc-pyrrolidine (s)-3-aminomethyl-pyrrolidine-1-carboxylicacidtert-butylester (s)-tert-butyl-3-(aminomethyl)pyrrolidine-1-carboxylate 3(s)-aminomethyl-pyrrolidine-1-carboxylicacidtert-butylester (s)-n-boc-3-(aminomethyl)pyrrolidine (s)-1-tert-butoxycarbonyl-3-(aminomethyl)pyrrolidine (S)-1-Boc-3-(Aminomethyl)pyrrolidine tert-butyl(3S)-3-(aminomethyl)pyrrolidine-1-carboxylate

Molecular Formula: C10H20N2O2

Molecular Weight: 200.28

MDL Number: MFCD02179397

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-1-Boc-3-(aminomethyl)pyrrolidine is a chiral, Boc-protected pyrrolidine derivative featuring an aminomethyl substituent at the 3-position. It serves as a versatile and crucial chiral building block in organic synthesis, particularly in the pharmaceutical industry. Its primary application is as a key intermediate in the synthesis of various bioactive molecules and active pharmaceutical ingredients (APIs). The chiral pyrrolidine scaffold is a privileged structure found in numerous drugs, especially those targeting the central nervous system (CNS). This compound is notably used in the synthesis of potent and selective norepinephrine reuptake inhibitors (NRIs), such as certain antidepressant candidates. The Boc-protected primary amine and the secondary amine (after Boc deprotection) provide handles for further functionalization and amide bond formation, making it a valuable precursor for constructing complex molecular architectures. The compound is typically handled under inert atmosphere due to the sensitivity of the Boc protecting group and the reactive amine functionality. It is commercially available from suppliers specializing in fine chemicals and advanced pharmaceutical intermediates, highlighting its established role in medicinal chemistry research and development.

Physical Properties

Boiling Point: 280.3 °C at 760 mmHg

Flash Point: 123.3 °C

Density: 1.044 g/cm3

Storage: 2-8°C