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    19752-55-7

    Catalog No. EBD40289

    CAS 19752-55-7

    Name 1-Bromo-3,5-dichlorobenzene

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    Basic Information

    Synonyms: 1-Bromo-3,5-dichlorobenzene

    Molecular Formula: C6H3BrCl2

    Molecular Weight: 225.9

    MDL Number: MFCD00000584

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates

    Product Description:
    1-Bromo-3,5-dichlorobenzene is a dihalogenated aromatic compound featuring a bromine atom at the 1-position and two chlorine atoms at the 3- and 5-positions on a benzene ring. With a molecular formula of C6H3BrCl2, it serves as a versatile building block in organic synthesis. This compound is primarily utilized as a synthetic intermediate for constructing more complex molecules via cross-coupling reactions, such as Suzuki, Heck, or Buchwald-Hartwig aminations, where the bromine atom acts as a reactive handle. It is commonly employed in the pharmaceutical industry for the preparation of drug candidates, particularly in the development of small-molecule drug fragments targeting neurological or inflammatory pathways. Additionally, it finds applications in agrochemical synthesis and material science for functionalized aromatic systems. Due to its stable crystalline nature and high reactivity under palladium-catalyzed conditions, it is a standard reagent in medicinal chemistry laboratories. Proper handling is required as it may cause skin and eye irritation.
    Physical Properties

    Melting Point: 73-75 °C(lit.)

    Boiling Point: 232 °C/757 mmHg(lit.)

    Flash Point: 232°C

    Density: 1.744 g/cm3

    Analytical Data

    Appearance: white to beige-brown crystalline powder

    mg g kg ml l t