N-(tert-butyloxycarbonyl)-4-fluorophenylglycine, CAS No. 196707-32-1

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196707-32-1

Catalog No. EBD2208316

CAS 196707-32-1

Name N-(tert-butyloxycarbonyl)-4-fluorophenylglycine

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Basic Information

Synonyms: (R)-N-BOC-4-Fluorophenylglycine (D)-N-tert-Butoxycarbonyl-alpha-(4-fluorophenyl)aceticacid (2R)-[(tert-butoxycarbonyl)amino](4-fluorophenyl)ethanoate Boc-4-fluoro-D-phenylglycine (r)-tert-butoxycarbonylamino-(4-fluoro-phenyl)-aceticacid (r)-n-boc-4-fluorophenylglycine(e.e.) (r)-n-boc-4-fluorophenylglycine95%(98%e.e.) (r)-n-boc-4-fluorophenylglycine,95%,ee:98% (r)-n-boc-4-fluorophenylglycine,98%ee (2R)-2-(4-fluorophenyl)-2-(tert-butoxycarbonylamino)acetate

Molecular Formula: C13H16FNO4

Molecular Weight: 269.27

MDL Number: MFCD01320889

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(R)-N-Boc-4-fluorophenylglycine is a chiral, non-natural amino acid derivative. It features a Boc-protected amino group and a 4-fluorophenyl substituent on the alpha carbon, which is in the (R)-configuration. This compound is a white to off-white crystalline powder. This molecule is a crucial chiral building block in pharmaceutical synthesis. Its primary application is as a key intermediate in the production of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and cardiovascular diseases. The presence of the fluorine atom and the chiral center is often essential for biological activity, metabolic stability, and receptor binding affinity in the final drug molecule. As a protected amino acid, it is widely used in peptide synthesis and medicinal chemistry research to introduce the (R)-4-fluorophenylglycine moiety into more complex structures. It serves as a versatile synthon for constructing peptidomimetics and small molecule drug candidates.

Physical Properties

Melting Point: 85.7 °C

Boiling Point: 408.4°Cat760mmHg

Flash Point: 200.8°C