4-(Fmoc-amino)-1-methyl-1H-pyrrole-2-carboxylic Acid, CAS No. 195387-29-2

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195387-29-2

Catalog No. EBD28046

CAS 195387-29-2

Name 4-(Fmoc-amino)-1-methyl-1H-pyrrole-2-carboxylic Acid

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Basic Information

Synonyms: 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-1-METHYL-1H-PYRROLE-2-CARBOXYLICACID 4-(9-FLUORENYLMETHOXYCARBONYL)AMINO-1-METHYLPYRROLE-2-CARBOXYLICACID 4-(FMOC-AMINO)-1-METHYL-1H-PYRROLE-2-CARBOXLYICACID 4-(FMOC-AMINO)-1-METHYL-1H-PYRROLE-2-CARBOXYLICACID 4-(FMOC-AMINO)-1-METHYLPYRROL-2-CARBOXYLICACID FMOC-PY-OH FMOC-NH(4)-MEPYL-(2)-OH FMOC-4-AMINO-1-METHYLPYRROLE-2-CARBOXYLICACID 4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-1-methyl-1H-pyrrole-2-carboxylicacid 4-(FMOC-AMINO)-1-METHYLPYRROL-2-CARBOXYLICA

Molecular Formula: C21H18N2O4

Molecular Weight: 362.38

MDL Number: MFCD02094546

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

4-(Fmoc-amino)-1-methyl-1H-pyrrole-2-carboxylic acid is a specialized heterocyclic building block featuring both an Fmoc-protected amino group and a carboxylic acid functional group on a 1-methylpyrrole core. This bifunctional structure makes it a valuable non-natural amino acid derivative for solid-phase peptide synthesis (SPPS). Its primary application is in the synthesis of peptidomimetics and modified peptides, where the pyrrole ring can serve as a constrained scaffold or a bioisostere to influence the peptide's conformation, stability, and biological activity. The Fmoc group is a standard protecting group for amines in Fmoc-based SPPS, allowing for sequential coupling and deprotection cycles. The carboxylic acid group enables its incorporation into the growing peptide chain. This compound is a key intermediate in medicinal chemistry research for developing novel therapeutic agents, particularly in areas targeting protein-protein interactions or requiring specific secondary structure induction. It is handled as a specialty fine chemical under standard laboratory safety protocols for organic compounds.

Physical Properties

Melting Point: ~210 °C (dec.)

Boiling Point: 559.1 °C at 760 mmHg

Flash Point: 291.9 °C

Density: 1.34 g/cm3