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    19481-82-4

    Catalog No. EBD115704

    CAS 19481-82-4

    Name 2-bromopropanenitrile

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    Basic Information

    Synonyms: 2-bromopropionitrile Propanenitrile,2-bromo- 2-bromopropanenitrile

    Molecular Formula: C3H4BrN

    Molecular Weight: 133.97

    MDL Number: MFCD00010383

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Cyano Compounds

    Product Description:
    2-Bromopropionitrile is an organic compound with the molecular formula C3H4BrN. It is a colorless to pale yellow liquid characterized by the presence of both a bromine atom and a nitrile (cyano) functional group on the same carbon chain. This bifunctional structure makes it a versatile and reactive building block in synthetic organic chemistry. Its primary application is as a key intermediate in the synthesis of various heterocyclic compounds and pharmaceuticals. For instance, it serves as a crucial precursor in the preparation of thiazole and imidazole derivatives, which are important scaffolds in medicinal chemistry. The bromine atom is a good leaving group for nucleophilic substitution reactions, while the nitrile group can be further transformed into carboxylic acids, amides, or reduced to amines, allowing for significant molecular diversification. Due to its high reactivity and the toxicity associated with both alkyl bromides and nitriles, 2-bromopropionitrile requires careful handling. It is typically used under controlled conditions in laboratory and industrial settings for the construction of more complex molecules rather than having a direct, standalone end-use application.
    Physical Properties

    Boiling Point: 68-69 °C/50 mmHg(lit.)

    Flash Point: 58 °C

    Density: 1.55 g/mL at 25 °C(lit.)

    Refractivity: n20/D 1.461(lit.)

    Safety Information

    Packing Level: III

    Hazard Category: 3

    Transport Codes: 1993C

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