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    19455-23-3

    Catalog No. EBD227518

    CAS 19455-23-3

    Name pivalic acid potassium salt

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    Basic Information

    Synonyms: pivalicacidpotassiumsalt potassiumpivalate tBuCO2K KOPiv trimethylaceticacidpotassiumsalt potassium2,2-dimethylpropionate potassium2,2-dimethylpropioate Propanoicacid,2,2-dimethyl-,potassiumsalt

    Molecular Formula: C5H9O2*K

    Molecular Weight: 140.22

    Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

    Product Description:
    Pivalic acid potassium salt is the potassium salt of trimethylacetic acid, with the molecular formula (CH_)_CCOOK. It appears as a white crystalline powder, highly soluble in water and polar organic solvents. Its structure features a sterically hindered tert-butyl group adjacent to the carboxylate, imparting unique reactivity and stability. This compound is primarily utilized as a versatile reagent in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions such as the Heck and direct arylation processes, where it acts as a base or a carboxylate ligand source to enhance catalytic activity and selectivity. In industrial applications, it serves as an additive in polymerization processes, a corrosion inhibitor in metalworking fluids, and a buffering agent in various chemical formulations. Its steric bulk also makes it valuable for preparing sterically hindered esters and as a precursor in the synthesis of pharmaceuticals and agrochemicals. Due to its hygroscopic nature, it should be stored in a dry, airtight container. It is generally considered low in acute toxicity but may cause irritation upon contact. Its role as a non-nucleophilic base and its ability to stabilize reactive intermediates make it a staple in both academic research and industrial chemical manufacturing.
    Physical Properties
    mg g kg ml l t