Fmoc - L - beta - homoleucine, CAS No. 193887-44-4

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193887-44-4

Catalog No. EBD30790

CAS 193887-44-4

Name Fmoc - L - beta - homoleucine

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Basic Information

Synonyms: (S)-3-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-methyl-hexanoicacid 3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-methylhexanoicacid hexanoicacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-methyl- fmoc-leu-(c*ch2)oh fmoc-l-beta-homoleucine fmoc-beta-holeu-oh fmoc-beta-homoleu-oh (3s)-n-3-(9-fluorenylmethoxycarbonyl)-3-amino-5-methyl-hexanoicacid (s)-3-(fmoc-amino)-5-methylhexanoicacid n-fmoc-3(s)-amino-5-methylhexanoicacid

Molecular Formula: C22H25NO4

Molecular Weight: 367.44

MDL Number: MFCD01863059

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Fmoc-L-β-homoleucine is a non-proteinogenic amino acid derivative. Its structure features a leucine side chain extended by one methylene unit (β-homologation) and is protected at the N-terminus with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This configuration makes it a valuable building block in solid-phase peptide synthesis (SPPS). The primary application of Fmoc-L-β-homoleucine is in the research and development of novel peptides and peptidomimetics. Incorporating β-amino acids like this one into peptide sequences can significantly alter the peptide's secondary structure, enhance metabolic stability against proteolytic degradation, and improve bioavailability. It is therefore crucial in medicinal chemistry for creating peptide-based drugs, enzyme inhibitors, and probes for biological studies. As a specialty Fmoc-protected amino acid, it serves as a key synthetic intermediate. Its use allows for the precise introduction of structural modifications to explore structure-activity relationships (SAR) and develop peptides with tailored pharmacological properties.

Physical Properties

Boiling Point: 572.1 °C at 760 mmHg

Flash Point: 299.8 °C

Density: 1.189 g/cm3

Storage: 2-8°C