(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid, CAS No. 193693-68-4

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193693-68-4

Catalog No. EBD14185

CAS 193693-68-4

Name (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid

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Basic Information

Synonyms: (2s,3's)-1-(3-methyl-2-methylamino-butyl)-pyrrolidin-3-ol2hcl (3s)-1,3-piperidinedicarboxylicacid1-(9h-fluoren-9-ylmethyl)ester (s)-1,3-piperidinedicarboxylicacid1-(9h-fluoren-9-ylmethyl)ester fmoc-l-nipecoticacid 1,3-piperidinedicarboxylicacid,1-(9h-fluoren-9-ylmethyl)ester,(3s)- fmoc-l-nip-oh fmoc-nip-oh (3S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperidine-3-carboxylicacid L-1-Fmoc-Nipecoticacid (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylicacid

Molecular Formula: C21H21NO4

Molecular Weight: 351.4

MDL Number: MFCD04112682

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

(S)-1-Fmoc-piperidine-3-carboxylic acid is a chiral, N-Fmoc-protected amino acid derivative featuring a piperidine ring. It serves as a crucial non-natural amino acid building block in solid-phase peptide synthesis (SPPS). The Fmoc group provides orthogonal protection for the amine functionality, allowing for selective deprotection under mild basic conditions. Its primary application is in the synthesis of peptides and peptidomimetics that incorporate constrained, cyclic structures to modulate biological activity, stability, and conformation. The piperidine scaffold is a privileged structure found in many pharmacologically active compounds, making this derivative valuable for medicinal chemistry research and the development of novel therapeutic agents, particularly in areas like protease inhibitors and GPCR-targeted drugs. This compound is a high-purity reagent used extensively in research laboratories for constructing complex peptide libraries and investigating structure-activity relationships. Proper handling requires standard precautions for laboratory chemicals.

Physical Properties

Boiling Point: 561.6°Cat760mmHg

Flash Point: 293.5°C

Density: 1.293g/cm3