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    19337-97-4

    Catalog No. EBD36286

    CAS 19337-97-4

    Name 3-(3-Pyridyl)acrylic acid

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    Basic Information

    Synonyms: 3-(3-Pyridyl)acrylicacid trans-3-(3-pyridyl)acrylicacid 3-(3-Pyridine)acrylicacid (E)-3-(3-pyridinyl)acrylicacid

    Molecular Formula: C8H7NO2

    Molecular Weight: 149.15

    MDL Number: MFCD00006410

    Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Synthetic Chemistry > Organic Building Blocks > C-C Double and Triple Bonds Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    3-(3-Pyridyl)acrylic acid is a heterocyclic compound featuring a pyridine ring conjugated with an acrylic acid moiety via a trans-configuration. Its structure combines a basic nitrogen-containing heterocycle with a carboxylic acid functional group, making it a versatile building block in organic synthesis. This compound is primarily utilized as a pharmaceutical intermediate, particularly in the synthesis of biologically active molecules targeting the central nervous system and inflammatory pathways. The pyridine ring can engage in hydrogen bonding and ж╨-ж╨ interactions, while the acrylic acid group allows for further derivatization through esterification, amidation, or conjugate addition reactions. It serves as a key precursor for developing drug candidates with improved pharmacokinetic properties. As a synthetic building block, it is also employed in the construction of coordination polymers, metal-organic frameworks (MOFs), and functional materials due to its ability to act as a bridging ligand. Its stability under standard laboratory conditions and solubility in polar organic solvents facilitate its use in diverse chemical transformations.
    Physical Properties

    Melting Point: 232-235 °C (dec.)(lit.)

    Boiling Point: 307.6 °C at 760 mmHg

    Flash Point: 139.8 °C

    Density: 1.261 g/cm3

    Storage: 2-8°C

    mg g kg ml l t