4-Boc-piperazine-2-carboxylic acid, CAS No. 192330-11-3

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192330-11-3

Catalog No. EBD9583

CAS 192330-11-3

Name 4-Boc-piperazine-2-carboxylic acid

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Basic Information

Synonyms: 4-BOC-PIPERAZINE-2-(R)-CARBOXYLICACID (2S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylicacid (2S)-4-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperazinecarboxylicacid 1,3-Piperazinedicarboxylicacid,1-(1,1-dimethylethyl)ester,(3S)- (2R)-4-(tert-butoxycarbonyl)piperazine-2-carboxylicacid R-4-Boc-piperazine-2-carboxylicacid R-4-N-Boc-2-CarboxylicAcidPiperazine R-4-N-Boc-2-PiperidineCarboxylicAcid (4-n-boc)piperazine(2r)cooh (r)-piperazine-1,3-dicarboxylicacid1-tert-butylester (r)-4-(tert-butoxycarbonyl)piperazine-2-carboxylicacid (r)-4-n-boc-piperazine-2-carboxylicacid (r)-4-boc-piperazine-2-carboxylicacid (s)-4-boc-2-piperazinecarboxylicacid (r)-1-boc-piperazine-3-carboxylicacid 1-Boc-piperazine-3-carboxylicacid 4-(tert-Butoxycarbonyl)piperazine-2-carboxylicacid Piperazine-1,3-dicarboxylicacid1-tert-butylester 4-Boc-piperazine-2-carboxylicacid 1,3-Pipe

Molecular Formula: C10H18N2O4

Molecular Weight: 230.26

MDL Number: MFCD01076218

Categories: Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

4-Boc-piperazine-2-carboxylic acid is a chiral piperazine derivative featuring a tert-butoxycarbonyl (Boc) protecting group at the 4-position and a carboxylic acid at the 2-position. Its molecular formula is C__H__N_O_, with a molecular weight of 230.26 g/mol. The compound exists as the (R)-enantiomer, making it a valuable chiral building block in asymmetric synthesis. This compound is primarily utilized as a key intermediate in the pharmaceutical industry for the synthesis of various bioactive molecules, including kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs. The Boc group provides orthogonal protection during multi-step synthesis, while the carboxylic acid and secondary amine functionalities allow for further derivatization, such as amide coupling or alkylation. Its chiral purity is critical for producing enantiomerically pure drug candidates. Due to its structural features, it is also employed in the development of peptide mimetics and as a scaffold in medicinal chemistry programs targeting G protein-coupled receptors (GPCRs) or proteases. The compound is typically stored at 2-8буC to maintain stability and is handled under standard laboratory conditions.

Physical Properties

Melting Point: 231-239 °C

Boiling Point: 371.785 °C at 760 mmHg

Flash Point: 178.649 °C

Density: 1.193 g/cm3