Harpagoside, CAS No. 19210-12-9

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19210-12-9

Catalog No. EBD582695

CAS 19210-12-9

Name Harpagoside

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Basic Information

Synonyms: Harpagosid (1S-(1alpha,4aalpha,5alpha,7alpha(E),7aalpha))-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(c)pyran-1-yl-beta-D-glucopyranoside 1-(hexopyranosyloxy)-4a,5-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl3-phenylprop-2-enoate (1S,4aS,5R,7S,7aS)-1-(beta-D-glucopyranosyloxy)-4a,5-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl(2E)-3-phenylprop-2-enoate hapagoside Harpagoside

Molecular Formula: C24H30O11

Molecular Weight: 494.49

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Phytochemicals and Natural Products Medicinal Chemistry > APIs and Their Salts > Other Drugs

Product Description:

Harpagoside is an iridoid glycoside, a type of natural product characterized by a cyclopentanopyran ring system (iridoid backbone) linked to a glucose moiety. It is a major bioactive constituent extracted from the roots of *Harpagophytum procumbens*, commonly known as devil's claw. Its primary application is in traditional and modern herbal medicine, where it is extensively studied for its potent anti-inflammatory and analgesic properties. Harpagoside is considered a key active pharmaceutical ingredient (API) in herbal medicinal products and dietary supplements used to alleviate symptoms of osteoarthritis, rheumatoid arthritis, tendonitis, and lower back pain. The mechanism of action is believed to involve the inhibition of pro-inflammatory enzymes like cyclooxygenase-2 (COX-2) and the modulation of inflammatory signaling pathways (e.g., NF-κB). Due to its natural origin and specific bioactivity, it is primarily categorized as a plant-derived chemical for pharmaceutical use. Research also explores its potential antioxidant and chondroprotective effects. Standardized extracts containing harpagoside are commercially important in the nutraceutical and phytopharmaceutical markets.

Physical Properties

Melting Point: 120°C (dec.)

Boiling Point: 720.7 °C at 760 mmHg

Flash Point: 244.3 °C

Density: 1.52 g/cm3