4-tert-Butyl N-[(tert-butoxy)carbonyl]-L-aspartate dicyclohexylamine salt, CAS No. 1913-12-8

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1913-12-8

Catalog No. EBD49605

CAS 1913-12-8

Name 4-tert-Butyl N-[(tert-butoxy)carbonyl]-L-aspartate dicyclohexylamine salt

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Basic Information

Synonyms: n-t-boc-l-asparticacidbeta-t-butylesterdicyclohexylammoniumsalt n-tert-boc-l-asparticacidbeta-tert-butylesterdicyclohexylammoniumsalt boc-l-asp(otbu)-ohdcha boc-l-asp(otbu)-oh(dicyclohexylammonium)salt Boc-L-Asp(Ot Boc-Asp(OtBu)-OH . DCHA N-T-boc-L-asparticacidB-T-butylesterdicyclohe Boc-Asp(OtBu)-OH.DCHA Boc-Asp(OBut)-OH*DCHA N-a-BOC-(b-O-tert-Bu)-L-Asp.DCHA (2S)-4-tert-butoxy-2-(tert-butoxycarbonylamino)-4-oxo-butanoicacid D-Asparticacid,N-[(1,1-dimethylethoxy)carbonyl]-,4-(1,1-dimethylethyl)ester,compd.withN-cyclohexylcyclohexanamine(1:1) Boc-Asp(OtBu)-OH·DCHA 4-Tert-ButylN-[(Tert-Butoxy)Carbonyl]-L-AspartateDicyclohexylamineSalt n-alpha-t-butoxycarbonyl-l-asparticacidbeta-t-butylesterdicyclohexylammoniumsalt n-alpha-tert-butyloxycarbonyl-l-asparticacidbeta-tert-butylesterdicyclohexylamine n-alpha-t-butyloxycarbonyl-l-asparticacidbeta-t-butylesterdicyclohexylamine n-alpha-t-boc-l-asparticacidbeta-t-butylesterdicyclohexylammoniumsalt

Molecular Formula: C25H46N2O6

Molecular Weight: 470.64

MDL Number: MFCD00038889

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

4-tert-Butyl N-[(tert-butoxy)carbonyl]-L-aspartate dicyclohexylamine salt is a protected derivative of the amino acid L-aspartic acid. It features two tert-butyl protecting groups: one on the α-amino group (Boc) and one on the β-carboxylic acid side chain (O-tBu). The compound is isolated as a dicyclohexylamine (DCHA) salt, which enhances its crystallinity, stability, and handling properties. This compound is a crucial chiral building block and pharmaceutical intermediate in peptide synthesis and medicinal chemistry. The Boc and O-tBu protecting groups are orthogonal to many other protecting group strategies and can be selectively removed under mild acidic conditions. Its primary application is in the solid-phase and solution-phase synthesis of peptides and peptidomimetics that contain aspartic acid residues, which are important in the development of various therapeutic agents, including enzyme inhibitors and bioactive peptides. The DCHA salt form facilitates purification and storage. As a high-purity, enantiomerically pure starting material, it is essential for ensuring the stereochemical integrity of the final peptide products. It is widely used in research and development for producing peptide-based drugs and biochemical probes.

Physical Properties

Boiling Point: 607.7 °C at 760 mmHg

Flash Point: 321.3 °C

Storage: −20°C