Phenothiazine-10-carbonyl chloride, CAS No. 18956-87-1

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18956-87-1

Catalog No. EBD44249

CAS 18956-87-1

Name Phenothiazine-10-carbonyl chloride

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Basic Information

Synonyms: 10H-Phenothiazine-10-carbonylchloride 1,1'-methanediylbis(4-tert-butylbenzene) 1-(1-Methylethyl)-1H-pyrazole 1-Isopropyl-1H-pyrazole Phenothiazine-10-carbonylchloride 10h-phenothiazine-10-car 10-chlorocarbonylphenothiazine. n-(chlorocarbonyl)phenothiazine phenothiazine-n-carbonylchloride 10h-phenothiazine-10-carboxylicacidchloride

Molecular Formula: C13H8ClNOS

Molecular Weight: 261.73

MDL Number: MFCD00044216

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Phenothiazine-10-carbonyl chloride is a reactive organic compound featuring a phenothiazine core functionalized with a carbonyl chloride group at the nitrogen position. This structure makes it a versatile acylating agent and a key synthetic intermediate. Its primary and most significant application is in the pharmaceutical industry as a crucial building block for the synthesis of various phenothiazine-derived drugs. It is specifically used to introduce the phenothiazine pharmacophore into target molecules, enabling the production of compounds with potential antipsychotic, antihistaminic, or other central nervous system activities. The carbonyl chloride group readily reacts with amines to form amide bonds, facilitating the creation of diverse drug candidates and active pharmaceutical ingredients (APIs). As a reactive intermediate, it is handled under inert conditions due to its sensitivity to moisture. Its utility extends beyond pharmaceuticals into materials science and organic synthesis research, where it serves as a precursor for functionalized phenothiazine derivatives used in dyes, charge-transport materials, and ligands.

Physical Properties

Melting Point: 168-172 °C

Boiling Point: 416.1°Cat760mmHg

Flash Point: 205.4°C

Density: 1.432g/cm3