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    188875-37-8

    Catalog No. EBD2760689

    CAS 188875-37-8

    Name (R)-tert-Butyl 2-amino-2-phenylethylcarbamate

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    Basic Information

    Synonyms: (R)-tert-Butyl2-amino-2-phenylethylcarbamate

    Molecular Formula: C13H20N2O2

    Molecular Weight: 236.31

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (R)-tert-Butyl 2-amino-2-phenylethylcarbamate is a chiral amine derivative featuring a phenethylamine scaffold protected by a tert-butoxycarbonyl (Boc) group on the primary amine. It is a white to off-white crystalline powder with a molecular formula of C13H20N2O2. This compound is a key chiral building block, specifically an (R)-configured β-amino acid precursor or a protected phenylethylenediamine analog. Its primary and significant application is in pharmaceutical research and development as a chiral intermediate. The (R)-stereochemistry is crucial for synthesizing biologically active molecules. It is extensively used in the preparation of various drug candidates, particularly those targeting the central nervous system (e.g., as a precursor for dopamine receptor ligands) and in the synthesis of peptidomimetics and enzyme inhibitors where the chiral 1,2-diamine motif is required. The Boc protecting group allows for selective deprotection under mild acidic conditions, facilitating further synthetic elaboration. While its main utility is as a specialized pharmaceutical intermediate, its well-defined structure and protected amine functionality also make it a valuable chiral synthon in asymmetric synthesis and medicinal chemistry for constructing complex molecules. Standard safety precautions for handling fine chemicals should be observed.
    Physical Properties
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